MK-677 (Ibutamoren)
An orally-active, non-peptide selective ghrelin receptor (GHS-R1a) agonist. Studied as a small-molecule growth hormone secretagogue with sustained GH-axis activation over 24 hours from a single dose.
Available formats
30 capsules × 10mg (300mg total)
MK677-30C-10MG
60 capsules × 10mg (600mg total)
MK677-60C-10MG
30 capsules × 25mg (750mg total)
MK677-30C-25MG
To place a research order, contact info@paradisecompounds.com.
Chemical Identity
| CAS Number | 159752-10-0 |
|---|---|
| Molecular Formula | C27H36N4O5S |
| Molecular Weight | 528.66 g/mol |
| Sequence | Non-peptide — small molecule (spiro-piperidine class) |
| Appearance | Capsules — white powder fill |
| Storage | Sealed, room temperature, away from light and moisture. |
Certificates of Analysis
Batch PLACEHOLDER-2026-A
Lot PC-MK677-2026-001 · Janoshik Analytical · 1/14/2026
99.2%
purity
Research Notes
MK-677 (Ibutamoren, MK-0677) is a small-molecule non-peptide selective ghrelin receptor (GHS-R1a) agonist. Unlike peptide growth hormone secretagogues, MK-677 is orally bioavailable and produces a sustained 24-hour elevation of GH-axis activity from a single daily dose.
Research interest
MK-677 has been extensively investigated in preclinical and clinical pharmacology research for:
- Ghrelin receptor selectivity and downstream cAMP/PLC signaling
- Pulsatile vs sustained GH release pharmacodynamics
- Comparison against peptide GHS compounds (GHRP-6, hexarelin, ipamorelin)
- Bone mineral density and body composition in older-adult research cohorts
Note on classification
MK-677 is not a peptide — it is a synthetic spiro-piperidine. We include it in the growth hormone secretagogue category because it serves the same research questions and customer base as peptide GHS compounds, but it is chemically distinct.
References
- PubMed query for Ibutamoren / MK-677
- Patchett AA, et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci. 1995.
This product is sold for laboratory and research use only. It is not intended for human consumption, in vitro diagnostic use, therapeutic use, or veterinary use.
All products sold on this site are intended strictly for laboratory and research use only. They are NOT intended for human consumption, in vitro diagnostic use, therapeutic use, or veterinary use. By purchasing from Paradise Compounds, you affirm that you are a qualified researcher and agree to use these materials in accordance with all applicable federal, state, and local laws.